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Herb library · Herb · Ananas comosus (pineapple plant)

Bromelain

A group of protein-digesting enzymes from pineapple stem and fruit, sold for pain and swelling after surgery, sinus trouble, joint pain and sore muscles. Some studies suggest it may ease symptoms after wisdom tooth surgery; a prescription bromelain product is used by professionals on severe burns.

Traditional use

Pineapple was used medicinally in South and Central America. Bromelain today is sold as a dietary supplement for pain after wisdom tooth removal, sinusitis, osteoarthritis and exercise-related muscle soreness. Separately, in 2022 the FDA approved a prescription bromelain product that health professionals apply to remove dead tissue from severe burns in adults; it is also approved in the European Union.

What studies show

  • Limited

    Wisdom tooth surgery: some studies suggest oral bromelain might reduce some symptoms, such as pain and swelling.

  • Insufficient

    Sinusitis: there is not enough high-quality research to say whether oral bromelain should be recommended.

  • Insufficient

    Osteoarthritis, sore muscles and other uses: very little research, or only studies of mixtures, so the effect of bromelain alone is unclear.

  • Established

    Severe burns (prescription only): an FDA-approved bromelain drug is applied by health professionals to remove dead tissue from severe burns, as an alternative to surgery. This is a hospital drug, not the dietary supplement.

Be careful of

Cautions

  • NoteTaken by mouth it seems well tolerated; the most commonly reported side effects are stomach upset and diarrhea.
  • InteractionSome herbs and medicines interact in harmful ways; ask before combining bromelain with any medicine.
  • PregnancyLittle is known about whether it is safe during pregnancy or while breastfeeding.
  • Ask a clinicianTalk with a clinician or pharmacist before using this if you take prescription medicines, are pregnant or breastfeeding, or are giving it to a child.

Sources

  1. Bromelain: Usefulness and Safety (opens in a new tab) · NCCIH · read September 25, 2026

Reviewed September 25, 2026.